2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine
2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine
CAS: 113520-22-2
Molecular Formula: C10H12N4O
2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine - Names and Identifiers
2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine - Physico-chemical Properties
| Molecular Formula | C10H12N4O |
| Molar Mass | 204.23 |
| Density | 1.267±0.06 g/cm3(Predicted) |
| Melting Point | 80-81 °C |
| Boling Point | 358.3±52.0 °C(Predicted) |
| pKa | 8.41±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD09743365 |
2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine - Risk and Safety
| Hazard Class | IRRITANT |
2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine - Introduction
2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine is an organic compound whose chemical formula is C10H11N5O. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine is a white solid.
-Solubility: Its solubility in water is low, but it is soluble in some organic solvents such as chloroform and dichloromethane.
-Melting point: The melting point of the compound is 110-112°C.
-Stability: It is a relatively stable compound at room temperature.
Use:
-Pharmaceutical field: 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine has antibacterial and antiviral activities, so it is used as a potential drug molecule in pharmaceutical research. It is also used as an intermediate for some anticoagulants and anticancer drugs.
Preparation Method:
The synthesis of compound 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine generally involves the following steps:
1. reacting oxazolo [4,5-b] pyridin -2-ol with phosphorus trichloride in an inert solvent to generate oxazolo [4,5-b] pyridin -2-ester.
2. oxazolo[4,5-b] pyridine-2-ester and piperazine undergo nucleophilic substitution reaction to generate 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine.
Safety Information:
There is limited safety information about 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine, so care should be taken during use and operation. The specific toxicity and potential hazards of the compounds are not fully understood, so laboratory safety guidelines and proper handling of chemicals must be followed. At the same time, appropriate personal protective measures should be followed, such as wearing gloves and goggles, and used in a well-ventilated area. In case of accidental application or contact with skin or eyes, seek medical attention immediately. Always observe safe handling procedures for chemicals when using this compound.
Nature:
-Appearance: 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine is a white solid.
-Solubility: Its solubility in water is low, but it is soluble in some organic solvents such as chloroform and dichloromethane.
-Melting point: The melting point of the compound is 110-112°C.
-Stability: It is a relatively stable compound at room temperature.
Use:
-Pharmaceutical field: 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine has antibacterial and antiviral activities, so it is used as a potential drug molecule in pharmaceutical research. It is also used as an intermediate for some anticoagulants and anticancer drugs.
Preparation Method:
The synthesis of compound 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine generally involves the following steps:
1. reacting oxazolo [4,5-b] pyridin -2-ol with phosphorus trichloride in an inert solvent to generate oxazolo [4,5-b] pyridin -2-ester.
2. oxazolo[4,5-b] pyridine-2-ester and piperazine undergo nucleophilic substitution reaction to generate 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine.
Safety Information:
There is limited safety information about 2-Piperazin-1-yl[1,3]oxazolo[4,5-b]pyridine, so care should be taken during use and operation. The specific toxicity and potential hazards of the compounds are not fully understood, so laboratory safety guidelines and proper handling of chemicals must be followed. At the same time, appropriate personal protective measures should be followed, such as wearing gloves and goggles, and used in a well-ventilated area. In case of accidental application or contact with skin or eyes, seek medical attention immediately. Always observe safe handling procedures for chemicals when using this compound.
Last Update：2024-04-09 21:54:55
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